Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice
- 1 August 1995
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 10 (4), 466-471
- https://doi.org/10.1038/ng0895-466
Abstract
We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.Keywords
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