Sinus histiocytosis with massive lymphadenopathy. Fifteen new casesd

Abstract
Fifteen cases of chronic lymphadenitis with massive hemophagocytic sinus histiocytosis were analyzed. Fourteen patients were whites, 13 were Europeans, and 11 were males; 10 patients were under 10, 4 were over 20, and 2 over 60 years old. The oldest patient died; all others either healed without therapy or are in excellent condition. We studied the cytologic features of lymph node imprints. A 5‐year‐old girl was examined more thoroughly. High antibody titers to Klebsiella antigens were found repeatedly. The patient also had a constant lymphocytopenia. Phytohemagglutinin‐induced blast transformation and lymphotoxin production were within normal limits. No serum Epstein‐Barr virus‐antibodies could be detected.