Dynamic Kinetic Resolution of 2-Oxocycloalkanecarbonitriles: Chemoenzymatic Syntheses of Optically Active Cyclic β- and γ-Amino Alcohols
- 15 August 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (19), 6816-6819
- https://doi.org/10.1021/jo0257288
Abstract
A series of fungi and yeasts have been tested for the stereoselective bioreduction of 2-oxocycloalkanecarbonitriles, 1. The yeast Saccharomyces montanus CBS 6772 yielded the corresponding cis-hydroxy nitriles, 2, in >90% ee and de and in high chemical yields. Through simple and efficient procedures, they were transformed into optically active 2-amino and 2-aminomethyl cycloalkanols.Keywords
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