Inhibition of Prothrombin Activation With Dextran

Abstract

Dextran inhibits threone activity, and fractions of low molecular weight are more effective in this respect than fractions of high molecular weight. Other poly-saccharides may also function as inhibitors of threone activity. A small amount of thrombin overcomes the inhibition with dextran provided it is added to prothrombin activation mixtures at the beginning of the interactions. It seems likely that a derivative of prothrombin does not form when the activation of prothrombin is inhibited with dextran.