NORMALIZATION OF THE INSULIN SENSITIVITY AND THE CELLULAR INSULIN BINDING DURING TREATMENT OF OBESE DIABETICS FOR ONE YEAR
- 1 January 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 90 (1), 103-112
- https://doi.org/10.1530/acta.0.0900103
Abstract
The relative importance of insulin resistance, decreased cellular insulin binding and relative insulin deficiency in the pathogenesis of diabetes mellitus in obese subjects was studied. Ten obese diabetics were studied before and during treatment for 1 yr with a 1200-1500 kcal diet. No change was found in the insulin response to i.v. injection of glucose during treatment (P < 0.1), whereas the insulin sensitivity was normalized after 1 yr (P < 0.01). In parallel to the clinical normalization and the improvement of the insulin sensitivity, the insulin binding to monocytes was normalized (P < 0.01). Both the insulin resistance and the relative insulin deficiency are of decisive importance in the pathogenesis of diabetes mellitus of the obese. The insulin receptor defect seems to be one of the major factors responsible for the insulin resistance.This publication has 6 references indexed in Scilit:
- Insulin receptors on monocytes of young healthy persons correlated with glucose tolerance and insulin sensitivityDiabetologia, 1978
- The monocyte as a model for the study of insulin receptors in manDiabetologia, 1977
- Insulin Binding in Diabetes: Relationships with Plasma Insulin Levels and Insulin SensitivityDiabetes, 1977
- The Insulin Receptor: Its Role in Insulin Resistance of Obesity and DiabetesDiabetes, 1976
- Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects.JCI Insight, 1976
- Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.JCI Insight, 1976