Correlation of serum aspirin esterase activity and half-life of Salicylic acid
- 1 December 1975
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 5 (5), 549-552
- https://doi.org/10.1007/bf01972693
Abstract
An inverse correlation was found between the serum aspirin esterase activity in human subjects and the biological half-life of salicylic acid in serum and a direct relationship between the values of the elimination rate constant and the activity of this enzyme. The rate of acetylsalicylic acid breakdown may be one of the factors which influences the biological half-like of salicylates in the organism and may participate also in determining the individual response to the administered drug.Keywords
This publication has 7 references indexed in Scilit:
- The influence of age on the activity of acetylsalicylic acid-esterase and protein-salicylate bindingEuropean Journal of Clinical Pharmacology, 1974
- Evidence for a Sex-linked Difference in Aspirin MetabolismNature, 1972
- Abnormal Aspirin Metabolism in Patients with Cirrhosis and Its Possible Relationship to Bleeding in CirrhoticsAnnals of Surgery, 1972
- Absorption Kinetics of Aspirin in Man follow Oral Administration of an Aqueous SolutionJournal of Pharmaceutical Sciences, 1972
- Variation in Rate of Salicylate Elimination by HumansBMJ, 1964
- SITE OF ACTION OF NARCOTIC + NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN1964
- Presence of Acetylsalicylic Acid in Plasma Following Oral Ingestion of AspirinExperimental Biology and Medicine, 1962