STUDIES ON THE PATHOGENESIS OF FEVER
Open Access
- 1 August 1967
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 126 (2), 385-394
- https://doi.org/10.1084/jem.126.2.385
Abstract
Macrophages from oil-induced peritoneal exudates in rabbits produce endogenous pyrogen when first activated by incubation in 4 hr exudate fluid and then stimulated by incubation in potassium-free isotonic sodium chloride solution. The failure of earlier investigators to obtain pyrogen from macrophages is explained, and the relevance of macrophage pyrogen to fevers of agranulocytosis and other diseases, in which mononuclear rather than granulocytic exudates predominate, is discussed.Keywords
This publication has 22 references indexed in Scilit:
- Human Leukocyte Pyrogen Producing Fever in Rabbits.Experimental Biology and Medicine, 1966
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1966
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1963
- Molecular mechanisms involved in the release of pyrogen from polymorphonuclear leucocytes.1962
- Absence of Endotoxic Activity in Materials Derived Without Bacterial Contamination from Mammalian TissueExperimental Biology and Medicine, 1960
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1958
- Studies on the pathogenesis of fever. III. Failure to demonstrate fever-producing substances in the tissues of leukopenic rabbits.1956
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1953
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1953
- THE FUNDAMENTAL PROPERTIES OF THE FIBROBLAST AND THE MACROPHAGEThe Journal of Experimental Medicine, 1926