Ototoxicity Induced by Furosemide

Abstract

FUROSEMIDE is a diuretic that has achieved wide use because of its great potency as a saluretic agent and its low order of toxicity. We describe here transient ototoxic effects of high-dose furosemide therapy in five patients with diminished renal function.Case ReportsA 37-year-old woman with marked renal impairment due to radiation nephritis and with normal hearing received a cadaveric renal transplant. A total of 3600 mg of furosemide was given intravenously in divided doses in the 1st 18 hours after transplantation. Sixty hours after transplantation the urine output fell from 80 to 20 ml per hour. A 1600-mg . . .