Effect of Pressor Amines and Adrenergic Blockade on Adrenal Ascorbic Acid Concentration in Rats

Abstract

Paredrine, a sympathomimetic amine, causes a significant decrease in adrenal ascorbic acid in normal rats but not in hypophysectomized rats. This effect of Paredrine and also that of epinephrine can be blocked by the prior admn. of Dibenzyline. Unlike Dibenamine, Dibenzyline itself does not bring about acute depletion of adrenal ascorbic acid in the doses used in this study. Pressor activity and ability to stimulate the pituitary-adrenal system do not seem to be related since ephedrine did not produce any depletion of adrenal ascorbic acid.