Influence of Female Hormones on Motility of Cat's Uterus and Its Responses to Oxytocics

Abstract

Normal mature, spayed, juvenile and pregnant cats were primed with an estrogen and progesterone in varying doses to determine the responsiveness of the uterus in vivo to oxytocics. Either type of hormone established some brief activity after injn. of oxytocics but both together were required to give a maximal and prolonged sensitivity to drugs. The two hormones in the cat are synergistic, or at least mutually complementary, and not antagonistic in respect to their effects upon the sensitivity of the cat''s uterus in vivo to drugs.