THE EXCRETION OF SULFANILAMIDE AND ACETYLSULFANILAMIDE BY THE HUMAN KIDNEY

Abstract

Simultaneous clearance tests of sulfanilamide, acetylsulfanilamide and inulin were made on a series of unselected human subjects and the data were analysed statistically. The mean clearance of sulfanilamide was found to be 0.45 times as great as the mean clearance of inulin in 82 detns. This result was interpreted as meaning that sulfanilamide is excreted by the human kidney by glomerular filtration plus tubular reabsorption. The mean clearance of acetylsulfanilamide was found to be almost identical with that of inulin in 95 detns. However, in individual cases the clearances of these 2 compounds were not always identical, but the degree of variations of these clearances were nearly the same. The clearances of sulfanilamide, acetylsulfanilamide and inulin were found to be independent of the urine flow.