Successful treatment of human genital herpes infections with 2-deoxy-D-glucose
- 29 June 1979
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 241 (26), 2798-2801
- https://doi.org/10.1001/jama.241.26.2798
Abstract
Thirty-six women with genital herpes infections (proved by virological or cytological means) were treated in a double-blind placebo-controlled study with the glucose analogue 2-deoxy-D-glucose for a three-week period. In initial mucocutaneous cases, 89% were cured, with two recurrences after 24 months; in the case of recurrent or secondary infections, 90% had a notable improvement manifested by no or less-frequent recurrences, fewer lesions, or shortened duration of symptoms. In initial infections, discomfort cleared within 12 to 72 hours of therapy; 90% of the patients were asymptomatic within four days. In both cases, virus shedding was notably reduced by 2-deoxy-D-glucose. Concomitant controls treated with placebos failed to respond within this time frame. The use of 2-deoxy-D-glucose provides a simple and unique approach to the treatment of genital herpesvirus infections. (JAMA241:2798-2801, 1979)This publication has 4 references indexed in Scilit:
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- Herpes simplex virus protein synthesis in the presence of 2-deoxy-d-glucoseVirology, 1976
- Preliminary biochemical characterization of the factors(s) responsible for herpesvirus-induced exogenous fusionJournal of Virology, 1976
- IN VIVO STUDIES WITH ANTIVIRAL AGENTS*Annals of the New York Academy of Sciences, 1965