Carcinoembryonic antigen in colorectal practice

Abstract

CEA, in combination with the time-honored barium enema, sigmoidoscopy, rectal examination with guaiac determinations, and thorough clinical history, is a useful tool for the colorectal surgeon in following the progression of disease in both colorectal carcinoma patients and patients who have certain premalignant conditions. In this high-risk group of patients, CEA determinations as well as colonoscopy are becoming increasingly useful. That tumors on the left side are associated with higher CEA levels than those on the right, side, due to vascular invasion or the grades of the tumors, and that often CEA antigenicity and severity of symptoms in ulcerative colitis correlate well, are emphasized. Finally, following total colectomy in five cases of ulcerative colitis, all CEA titers decreased to the normal range and have remained there.