Natural and antibody‐dependent killer cells in the thymus
- 1 January 1982
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 12 (11), 914-921
- https://doi.org/10.1002/eji.1830121105
Abstract
Thymocytes contain a small population of light (ϱ = 1.067), large cells with high cytolytic potential against natural killer target as well as against IgG- or IgM-coated erythrocytes and nucleated cells, thus displaying natural killer and antibody-dependent cellular cytotoxicity functions, but not exhibiting T killer cell capacity. As far as characterized, the cells show T cell characteristics: they are nonadherent, nonphagocytic, surface immunoglobulin-negative, C3 receptor-negative, partly Fey receptor-positive, carry the receptor for Helix pomatia A agglutinin, and are, at least partly, cortisone-resistant and Thy-1-positive. The implications of this finding with respect to the lineage of natural killer and killer cells and their interdependence will be discussed briefly.Keywords
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