HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia
Open Access
- 1 November 2001
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 15 (13), 2445-2453
- https://doi.org/10.1096/fj.01-0125com
Abstract
Adaptation to hypoxia is regulated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor consisting of an oxygen-regulated α subunit and a constitutively expressed β subunit. Al...Keywords
This publication has 43 references indexed in Scilit:
- Accumulation of HIF-1α under the influence of nitric oxideBlood, 2001
- Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor proteinThe EMBO Journal, 2000
- Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor ProteinJournal of Biological Chemistry, 2000
- Hypoxia-Induced Vascular Endothelial Growth Factor Expression Precedes Neovascularization after Cerebral IschemiaThe American Journal of Pathology, 2000
- p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1Journal of Biological Chemistry, 1999
- Characterization of an Oxygen/Redox-Dependent Degradation Domain of Hypoxia-Inducible Factor α (HIF-α) ProteinsBiochemical and Biophysical Research Communications, 1999
- The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factorsProceedings of the National Academy of Sciences, 1998
- Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1αGenes & Development, 1998
- Hypoxia, a Novel Inducer of Acute Phase Gene Expression in a Human Hepatoma Cell LinePublished by Elsevier ,1995
- Cell size regulation, a mechanism that controls cellular RNA accumulation: consequences on regulation of the ubiquitous transcription factors Oct1 and NF-Y and the liver-enriched transcription factor DBP.The Journal of cell biology, 1995