URINARY EXCRETION OF β-CORTOLONE (3α,17α, 20β,21-TETRAHYDROXYPREGNANE-11-ONE) IN YOUNG AND ELDERLY MEN AND WOMEN*
- 1 July 1959
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 19 (7), 819-826
- https://doi.org/10.1210/jcem-19-7-819
Abstract
[beta]-Cortolone (3[alpha]r,17[alpha],20[beta],21-tetrahydroxypregnane-ll-one) was found as a regularly occurring metabolite in the urine of 20 young and elderly subjects of both sexes. The range of excretion values for young subjects was 0.3 to 2.9 mg. per twenty-four hours, and that for elderly subjects was 0.4 to 1.0 mg per twenty-four hours. When expressed as a function of creatinine excretion, [beta]-cortolone excretion was not significantly altered by age. It was, however, significantly correlated (r = 0.91) and proportional (20.1 per cent [plus or minus] 1.5) to the urinary excretion of tetrahydrocortisol, allqtetrahydro-cortisol and tetrahydrocortisone.Keywords
This publication has 7 references indexed in Scilit:
- THE URINARY EXCRETION OF ETRAHYDROCORTISOL, 3α-ALLOTETRAHYDROCORTISOL AND TETRAHYDROCORTISONE IN YOUNG AND ELDERLY MEN AND WOMEN*Journal of Clinical Endocrinology & Metabolism, 1958
- A Comparison of Urinary Steroid Excretion Patterns in Young and Elderly Subjects Before and After Acth AdministrationJournal of Gerontology, 1957
- DETERMINATION OF TETRAHYDROCORTISOL AND TETRAHYDROCORTISONE IN THE URINE OF NORMAL AND SCHIZOPHRENIC MEN*Journal of Clinical Endocrinology & Metabolism, 1957
- DETECTION OF C-21 GLYCEROL SIDE CHAIN STEROIDS ON PAPER CHROMATOGRAMSEndocrinology, 1955
- THE CHARACTERIZATION OF FOUR NEW METABOLITES OF ADRENOCORTICAL HORMONESJournal of Biological Chemistry, 1955
- The oxidation of corticosteroids with sodium bismuthateBiochemical Journal, 1953
- A SIMPLE METHOD FOR ANALYZING COMPLICATED ABSORPTION CURVES, OF USE IN THE COLORIMETRIC DETERMINATION OF URINARY STEROIDSJournal of Clinical Endocrinology & Metabolism, 1950