THE CONVERSION OF DESOXYCORTICOSTERONE ACETATE TO A PROGESTERONE-LIKE SUBSTANCE1
- 1 May 1955
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 56 (5), 511-515
- https://doi.org/10.1210/endo-56-5-511
Abstract
Conversion of desoxycorticosterone acetate to progestin was studied in 2 mammalian spp. Following administration of DCA to castrated or castrated-adrenal-ectomized rats, maximal increases in serum progestin concentration were observed within 4 hours with a return to normal within 24 hours. Similar results, but of a lower order of magnitude, were seen when castrated-nephrectomized rats were used. No conversion was detected in castrated rats deprived of their kidneys and adrenal glands. Administration of DCA to castrated and castrated-hepatectomized rabbits caused an increase in circulating progestin similar to that obtained in the rat. Removal of the kidneys resulted in a significantly decreased conversion. Incubation of rat tissues with and without addition of DCA indicated the possibility that the kidneys and the adrenal glands are involved in the conversion of DCA to progestin.Keywords
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