MICROGRANULAR ACUTE PROMYELOCYTIC LEUKEMIA - DISTINCT CLINICAL, ULTRASTRUCTURAL, AND CYTOGENETIC ENTITY
- 1 January 1980
- journal article
- research article
- Vol. 55 (2), 253-259
Abstract
Three patients with acute leukemia, disseminated intravascular coagulation and a specific acquired chromosome abnormality [t (15;17)] were found by transmission electron microscopy to have the typical distribution of granules seen in promyelocytes. Average granule sizes were 120, 170 and 180 nm, respectively, for the 3 patients, significantly less than the 250 nm resolution of light microscopy. The leukemia in these 3 patients was regarded as comprising a distinct clinical, ultrastructural and cytogenetic entity called microgranular acute promyelocytic leukemia.This publication has 9 references indexed in Scilit:
- T (15-17) TRANSLOCATION IN ACUTE PROMYELOCYTIC AND ACUTE NON-PROMYELOCYTIC LEUKEMIA1979
- Acute promyelocytic leukemiaAmerican Journal Of Medicine, 1978
- Correlation of Clinical Findings with Quinacrine-Banded Chromosomes in 90 Adults with Acute Nonlymphocytic LeukemiaNew England Journal of Medicine, 1978
- Unusual Configurations of Endoplasmic Reticulum in Cells of Acute Promyelocytic LeukemiaJNCI Journal of the National Cancer Institute, 1978
- Prophylactic heparin therapy in acute promyelocytic leukemiaCancer, 1978
- HYPERGRANULAR PROMYELOCYTIC LEUKEMIA (APL) - CYTOGENETIC AND ULTRASTRUCTURAL SPECIFICITY1978
- 15/17 Translocation in acute promyelocytic leukaemiaHuman Genetics, 1978
- Further evidence for a non‐random chromosomal abnormality in acute promyelocytic leukemiaInternational Journal of Cancer, 1977
- Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative GroupBritish Journal of Haematology, 1976