Effects of Methylazoxymethanol Acetate on Inbred Mice: Influence of Genetic Factors on Tumor Induction

Abstract

Three inbred strains of mice, AKR/J, SWR/J, and C57BL/6J, showing differential response to dimethylhydrazine (DMH)-induced colorectal tumors, were given s.c. injections 1 .times. a wk for 10 wk with 20 mg methylazoxymethanol (MAM) acetate/kg body wt. Colorectal tumors occurred in nearly 100% of the SWR/J mice and 77% of C57BL/6J mice that survived 20 or more weeks after the 1st injection. Three C57BL/6J mice and 1 SWR/J mouse developed anal tumors. None of the AKR/J mice developed colorectal or anal tumors; a possible factor could have been the earlier deaths of animals, mostly from leukemia. The influence of genetic background on the susceptibility to MAM acetate-induced colorectal tumors is discussed.