Causation of Stones by 2 Co-Acting Agents—Diamox and Operative Insult Upon Urinary Tract

Abstract

Study on adult Harlan male rats revealed that severe and generalized urolithiasis developed after administration of diamox and implantation of a foreign body in the bladder. Neither diamox nor foreign body implantation alone resulted in stone growth. Diamox induced precipitation of magnesium ammonium phosphate. . Sham operated animals without the foreign body implant and treated with diamox also developed stones in all parts of the urinary system.