Cerebrospinal fluid biochemical markers of central nervous system metastases
- 1 December 1980
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 8 (6), 597-604
- https://doi.org/10.1002/ana.410080609
Abstract
β-Glucuronidase and carcinoembryonic antigen (CEA) were measured in the cerebrospinal fluid of patients with cancer. Both substances were found to reliably detect the presence of leptomeningeal infiltration by carcinoma. Neither substance was reliable in the detection of leptomeningeal infiltration by lymphoma or of metastases to the brain parenchyma or spinal epidural space. β-Glucuronidase was moderately elevated in chronic infectious meningitis, whereas CEA was not. Both markers approached control levels with favorable treatment of the leptomeningeal metastases, reflecting the effectiveness of treatment. Both β-glucuronidase and CEA hold promise as indicators of early metastatic involvement of the leptomeninges by carcinoma.Keywords
This publication has 19 references indexed in Scilit:
- SERUM-ALPHA1-FETOPROTEIN IN PATIENTS WITH TESTICULAR TUMOURSThe Lancet, 1976
- Present and Probable Uses of CEACA: A Cancer Journal for Clinicians, 1975
- Increased polyamine concentrations in the cerebrospinal fluid of patients with brain tumorsInternational Journal of Cancer, 1974
- Carcinoembryonic antigen (CEA) in colonic cancer. Use in preoperative and postoperative diagnosis and prognosisPublished by American Medical Association (AMA) ,1972
- Early differentiation of chronic meningitis by enzyme assayNeurology, 1968
- -Glucuronidase Activities in Cerebrospinal FluidArchives of Neurology, 1964
- A note on the determination of serum beta-glucuronidase activityJournal of Clinical Pathology, 1961
- Glutamic oxalacetic transaminase (GOT) and lactic dehydrogenase (LDH) activitiesNeurology, 1959
- Lactic Dehydrogenase of Cerebrospinal Fluid in the Differential Diagnosis of Cerebrovascular Disease and Brain TumorJournal of Neurosurgery, 1958
- Glutamic‐Oxalacetic Transaminase Activity in Spinal FluidNeurology, 1957