Influence of Fasting on the Effect of Insulin on Glucose Oxidation.

Abstract

The oxidation of glucose to CO2 was studied with and without insulin in eviscerated rabbits. The blood sugar of the animals was maintained at a normal level for 8 hrs. by the constant injn. of C14-labeled glucose. The avg. glucose oxidation for the 8 hrs. of observation was with insulin and no fast, 199; 1-day fast, 114; 4-day fast, 52; and without insulin 30 mg./ kg./hr. The usual effect of fasting on glucose disappearance (utilization) is noted. Glucose "utilization" with insulin and no fast was 660; 1-day fast, 540; 4-day fast, 258; and without insulin 112 mg./kg./hr.