Effect of Androstene Derivatives on Metacorticoid Hypertension
- 1 November 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 84 (2), 262-263
- https://doi.org/10.3181/00379727-84-20611
Abstract
The following compounds were tested for depressor activity in metacorticoid (post-DCA) hypertensive rats: testosterone and its 11[beta]-OH and 11=O derivatives, adrenosterone, androstenedione, and its 11[beta] -OH derivative. Results indicated that replacement of the 11-OH by -H or =O appeared to decrease the activity of the 17-ketosteroids and increase that of the 17-hydroxysteroids. The depressor activity could not be related to anabolic or androgenic activity.Keywords
This publication has 5 references indexed in Scilit:
- Response of Metacorticoid Hypertension to Bistrium, Apresoline, Veriloid and SerpentinaExperimental Biology and Medicine, 1953
- Self-Sustaining, Post-DCA Hypertensive Cardiovascular DiseaseAmerican Journal of Physiology-Legacy Content, 1952
- Mechanisms of Desoxycorticosterone Action VII. Influence of the PituitaryAmerican Journal of Physiology-Legacy Content, 1952
- A NEW METHOD FOR THE INDIRECT MEASUREMENT OF BLOOD PRESSURE IN THE RAT1947
- Prevention of Experimental Nephrosclerosis with Methyl-TestosteroneJournal of Urology, 1944