Regional Flow-Pressure Relationship in Response to Angiotensin in the Intact Dog and Sheep

Abstract

The effects of intravenous administration of angiotensin on the arterial pressure and on the renal, carotid, iliac, uterine, and femoral blood flows were investigated in dogs and sheep through the use of implanted electromagnetic flowmeters. The rise in arterial pressure was immediate and, within the range of doses employed, presented little relation ship to the dose. The pressor effect of angiotensin was accompanied by a consistent fall in the renal blood flow and a rise in the femoral, iliac, and uterine flows. Carotid flow was less affected. These studies demonstrate the specificity of flow response to a given change in pressure in the various areas of the body.