Further Studies in Experimental Allergic Encephalitis in the Guinea Pig

Abstract

Rabbit, guinea pig, human, calf, and swine brain tissue plus adjuvants were used as antigens. Sub-cut. injns. were made into guinea pigs, and the development of allergic encephalitis or death was noted. Approx. 35 to 66% of the animals showed positive reactions with each type of brain tissue used. The negative animals were then injd. intracerebrally with 0.1 ml. of brain antigen, this caused the death of the majority. Homologous antigen was a particularly effective killer on intra-cerebral inoculation. Complement-fixation antibodies were demonstrated.