Zur Streptomycinschädigung Des Ganglion Spirale
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 85 (1-6), 360-362
- https://doi.org/10.3109/00016487809121464
Abstract
The neuronal density in the spiral ganglion was investigated in normal and in streptomycin-intoxicated guinea pigs. Streptomycin was administered in a dose of 250 mg/kg for 21 days. Six weeks after the streptomycin exposure a histological examination revealed a decrease in ganglion cell density in the spiral ganglion, with maximum loss in the apical portion of the ganglion. As mechanisms of the ototoxic effect, a secondary degeneration of spiral ganglion cells after hair cell loss or a primary neurotoxic degeneration are discussed.This publication has 8 references indexed in Scilit:
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