Experimental Urolithiasis IV: Prevention of Magnesium Ammonium Phosphate Calculi by Reducing the Magnesium Intake or by Feeding an Aluminum Gel

Abstract

Stones formed in rats after the introduction of a foreign body in the bladder are composed primarily of Mg ammonium phosphate hexahydrate. Calculi could be prevented by reducing the concn. in the urine of either the Mg or the phosphate. Reduction of Mg in the urine was accomplished by reducing the Mg in the diet. Phosphate excretion was reduced by feeding large amts. of basaljel, a gel of basic Al carbonate. Other expts. showed that stones previously formed could be dissolved in many instances by the same measures. The validity of these conclusions is affirmed in each expt. by application of the statistical "t-test." The expts. support the use of basaljel in human cases of phosphate urolithiasis.