CIRCULATING CORTICOTROPHIN IN NORMAL AND ADRENALECTOMIZED RATS AFTER STRESS

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Abstract
Sham adrenalectomy under ether anesthesia in intact rats and ether aesthesia alone in adrenalectomized rats causes a rapid rise and fall in the blood level of adrenocorticotropic hormone with similar time relationships in both groups of animals. Adrenocorticotropic hormone became detectable in the blood of adrenalectomized rats 10 days after the removal of the adrenal glands. The hormone concentration increased to 10 m[mu]/100 ml blood 3 weeks after adrenalectomy and persisted at this level for a minimum of 2 additional weeks. The increase in the level of circulating adrenocorticotropic hormone caused by anesthetizing adrenalectomized rats with ether depended upon the resting level of the hormone.