Inhibition of Respiration in Tetrahymena pyriformis S by Actidione

Abstract
[logn dash]Actidione at pH 6.0 sharply inhibits the endogenous respiration of T. pyriformis S, as well as its utilization of fructose, galactose, glucose, mannose, maltose, acetate, [alpha]-ketoglutarate, lactate, malate, pyruvate, glutamic acid, and tryptophan. Ribose, rhamnose, citrate, succinate, and lysine did not stimulate respiration. The site of action of actidione seems to be common to many reactions and may be of a nonspecific nature.