STUDY ON RACEMIZATION IN OXIDATION-REDUCTION CONDENSATION BY THE COUPLING REACTION FOR THE FORMATION OF BOC-LEU-ILE-ASP(NH2)-LEU-OBUt
- 5 July 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 6 (7), 719-722
- https://doi.org/10.1246/cl.1977.719
Abstract
Racemization in the oxidation-reduction condensation was studied by the coupling reaction for the formation of Boc-Leu-Ile-Asp(NH2)-Leu-OBut , recently reported for the detection of racemization in the azide, dicyclohexylcarbodiimide +1-hydroxybenzotriazole methods, etc. The coupling reaction using triphenylphosphine and 2,2′-dithiodipyridine-1,1′-dioxide gave favorable results to the present racemization test on solid support as well as in solution synthesis.Keywords
This publication has 7 references indexed in Scilit:
- Solid Phase Peptide Synthesis by Oxidation-Reduction Condensation. Synthesis of Adrenocorticotropin(1–24) by Chain Elongation at the Carboxyl End on Solid SupportBulletin of the Chemical Society of Japan, 1976
- Solid phase peptide synthesis by oxidation-reduction condensationJournal of the American Chemical Society, 1975
- Solid Phase Peptide Synthesis by Oxidation-Reduction Condensation. Synthesis of LH–RH by Fragment Condensation on Solid SupportBulletin of the Chemical Society of Japan, 1973
- Use of propionic acid-hydrochloric acid hydrolysis in Merrifield solid-phase peptide synthesisThe Journal of Organic Chemistry, 1972
- Peptide Synthesis by Oxidation-Reduction Condensation. II. The Use of Disulfide as an OxidantBulletin of the Chemical Society of Japan, 1971
- Hard and Soft Acids and BasesJournal of the American Chemical Society, 1963
- The Factors Determining Nucleophilic ReactivitiesJournal of the American Chemical Society, 1962