QUANTITATIVE STUDY OF ANTAGONISM OF ESTROGEN AND PROGESTERONE IN CASTRATE RABBIT1

Abstract

A quantitative ratio is present when optimal amts. of estrogen and progesterone are used, and the expts. of Robson are confirmed. When estrogen is increased, the progestational reaction is diminished or inhibited. When large amts. of both hormones are used in a ratio which was effective in producing a progestational reaction in the optimal range, the progestational response is reduced or inhibited. The progestational proliferation is dependent on the presence of optimal amounts of estrogen and progesterone, and cannot be represented as following a mathematical law of direct proportional variation.