MEASUREMENT OF ALCOHOL-RELATED EFFECTS IN MAN - CHRONIC EFFECTS IN RELATION TO LEVELS OF ALCOHOL CONSUMPTION .A.
- 1 January 1977
- journal article
- research article
- Vol. 141 (5), 235-248
Abstract
The effects of chronic alcohol ingestion are quantitatively related to intake, but little information is available on the topic. In Part A of this review, intake-effect relationships are examined for chronic dysfunctions of the liver, pancreas, cardiovascular system, testis and fetus. Part B considers CNS effects such as the withdrawal syndrome, psychosis, brain damage, memory loss, alterations of attention, sleep disturbances and EEG changes. Alcohol and the elderly, evidence of favorable effects of alcohol and the question of alcoholism are also discussed. In the vast majority of studies the documented daily intake levels were over 150 g of ethanol (the equivalent of 1 pint of 80 proof spirits), often in the range of 250-300 g. Other potential risk factors such as malnutrition are rarely considered, and little information is available on the effects of more moderate daily intake. The liver emerges as the most vulnerable organ to regular alcohol use with the hazardous range beginning at a daily intake of 80-100 g of ethanol. There is some evidence of beneficial effects, especially in the elderly, of daily intakes of 15-30 g and epidemiological evidence of a lower incidence of myocardial infarction in those with a daily intake approximately 56 g. MOre information is needed on chronic intake-effect relationships, particularly at levels below 150 g.This publication has 25 references indexed in Scilit:
- Alcohol Consumption Before Myocardial InfarctionAnnals of Internal Medicine, 1974
- The Natural Course of Alcoholic CardiomyopathyAnnals of Internal Medicine, 1974
- Chronic PancreatitisAnnals of Internal Medicine, 1971
- Observations on 205 confirmed cases of acute pancreatitis, recurring pancreatitis, and chronic pancreatitis.Gut, 1965
- A Longitudinal Study of Coronary Heart DiseaseCirculation, 1963
- The Concentration of Apparent Endogenous EthanolQuarterly Journal of Studies on Alcohol, 1962
- Alcoholic cardiomyopathyAmerican Heart Journal, 1961
- Clinical Evaluation of Blood Pressure in AlcoholicsQuarterly Journal of Studies on Alcohol, 1958
- Direct Determination of Maximal Daily Metabolism of AlcoholScience, 1952
- Maximal Consumption of Ethyl AlcoholScience, 1949