Effects of Epinephrine on Lipid Partition and Metabolism in the Rabbit

Abstract

Epinephrine overdosage in intact rabbits caused significant modifications in plasma lipid distribution and transport, and phospholipid metabolism of plasma, liver and aorta. Aortic phospholipid synthesis was accelerated shortly after epinephrine injection and persisted for 24 hours, but plasma and liver turnover rates were maximally elevated after 48 hours. Changes in plasma neutral fat concentration were paralleled by alterations in the levels of S_f 12-400 lipoproteins and a relationship between S_f 0-12 and plasma cholesterol levels is suggested by the data.