Differential equation model to study dynamic behaviour of globular proteins
- 1 August 1984
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 24 (2), 168-179
- https://doi.org/10.1111/j.1399-3011.1984.tb00943.x
Abstract
By regarding the globular proteins as spheroidal shaped bodies of uniform density, a differential equation model to study their low amplitude fluctuations was developed. It was then applied to the crystal structures of [bovine] pancreatic trypsin inhibitor and [tuna] ferrocytochrome c. The results were tested by comparing them with those of the dynamic simulation and temperature factor studies on the same proteins.Keywords
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