THE INFLUENCE OF THE SERUM BROMIDE CONCENTRATION UPON THE DISTRIBUTION OF BROMIDE ION BETWEEN SERUM AND SPINAL FLUID

Abstract

Quantitative studies on the distribution ratio of bromide ion between serum and spinal fluid revealed that, in dogs, the value of the distribution ratio Br- s: Br- sp. fl. varied in an inverse manner to the serum bromide conc. At serum bromide levels of 1-10 mM Br/Kg H2O the avg. value of the ratio was 1.78; at serum bromide levels of 20 to 50 mM/Kg H2O the avg. value of the ratio was 1.25; and at high serum bromide levels (70 to 95 mM Br/Kg H2O) avg. value of the ratio was 1.09. Reasons for these findings are suggested.