Evidence-Based Review on the Effect of Normal Dietary Consumption of Fructose on Blood Lipids and Body Weight of Overweight and Obese Individuals
- 22 November 2010
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Food Science and Nutrition
- Vol. 50 (10), 889-918
- https://doi.org/10.1080/10408398.2010.512990
Abstract
Although some investigators have hypothesized that ingestion of fructose from foods and beverages is responsible for the development of hyperlipidemia or obesity, a recent evidence-based review demonstrated that there was no relationship between the consumption of fructose in a normal dietary manner and the development of hyperlipidemia or increased weight in normal weight individuals. Because overweight and obese individuals may exhibit metabolic abnormalities such as insulin resistance, impaired glucose tolerance, hyperlipedemia, and/or alterations in gut hormones involved in appetite regulation, the findings of fructose studies performed in normal weight subjects may not be particularly relevant for overweight or obese subjects. A systematic assessment of the strength and quality of the studies and their relevance for overweight or obese humans ingesting fructose in a normal dietary manner has not been performed. The purpose of this review was to critically evaluate the existing database for a causal relationship between the ingestion of fructose in a normal, dietary manner and the development of hyperlipidemia or increased body weight in overweight or obese humans, using an evidence-based approach. The results of the analysis indicate that there is no evidence which shows that the consumption of fructose at normal levels of intake causes biologically relevant changes in triglycerides (TG) or body weight in overweight or obese individuals.Keywords
This publication has 71 references indexed in Scilit:
- Fructose Consumption: Considerations for Future Research on Its Effects on Adipose Distribution, Lipid Metabolism, and Insulin Sensitivity in HumansJournal of Nutrition, 2009
- The glycaemic index values of foods containing fructose are affected by metabolic differences between subjectsEuropean Journal of Clinical Nutrition, 2009
- Endocrine and Metabolic Effects of Consuming Fructose- and Glucose-Sweetened Beverages with Meals in Obese Men and Women: Influence of Insulin Resistance on Plasma Triglyceride ResponsesJournal of Clinical Endocrinology & Metabolism, 2009
- Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humansJCI Insight, 2009
- Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrupThe American Journal of Clinical Nutrition, 2008
- Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese womenBritish Journal of Nutrition, 2008
- Urinary sucrose and fructose as biomarkers of sugar consumption: comparison of normal weight and obese volunteersInternational Journal of Obesity, 2008
- Dietary Complex Carbohydrates and Low Glycemic Index/Load Decrease Levels of Specific Metabolic Syndrome/Cardiovascular Disease Risk FactorsTopics in Clinical Nutrition, 2008
- Glycaemic index effects on fuel partitioning in humansObesity Reviews, 2006
- Turku sugar studies XI: Effects of sucrose, fructose and xylitol diets on glucose, lipid and urate metabolismActa Odontologica Scandinavica, 1976