Neurological Changes Associated with P.A.S. and I.N.A.H. Therapy

Abstract

Shortly after isoniazid (I.N.A.H.) was first used in the treatment of tuberculosis, it became apparent that side-effects were not uncommon. Thompson (1952) lists euphoria, hyperreflexia, vertigo, muscular twitching, insomnia, paraesthesiae and transient loss of memory among the reactions observed. These were noted to be mild and reversible but did suggest involvement of the nervous system.