Acromegaly Treated with Chlorpromazine

Abstract

Short-term therapy with chlorpromazine, medroxyprogesterone acetate and a combination of the two drugs was given to a young man with active acromegaly. Serial levels of serum growth hormone with the patient fasting and during six-hour oral glucose tolerance tests were determined before any treatment, during treatment and between treatment periods. There was a marked decrease in fasting levels by the 12th day of each treatment period. On the 10th day of chlorpromazine therapy the fasting level was still above normal, though decreased from the base-line level. On the 12th and 17th days of this therapy fasting concentrations were near the normal range. The clinical manifestations improved during the course of chlorpromazine therapy.