On Natural Auto-Antibodies as Evidenced by Anti-Venin in Serum and Liver Extract of the Gila Monster
- 1 July 1946
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 32 (7), 195-201
- https://doi.org/10.1073/pnas.32.7.195
Abstract
Auto-antivenin capable of neutralizing the effect of a fatal dose (6 to 10 MLD) of the venom of Heloderma suspectum in mice was found in the globulin fraction of Heloderma serum and in extract of the liver of a pilocarpine-injd. Heloderma. Extracts of venom gland, spleen and kidney, and serum of rabbit and chuckwalla had no such effect. On the basis of the auto-antibody hypothesis it is suggested that the auto-antivenin may be synthesized in the same cells (perhaps in the liver) as the venom; after liberation into the blood stream the venom gland would effect a separation, accumulating the venom, which is later secreted, while the antivenin is left in the blood.Keywords
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