THE METABOLISM OF RADIOESTRONE IN THE RAT
- 1 December 1955
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 57 (6), 692-699
- https://doi.org/10.1210/endo-57-6-692
Abstract
In the rat given estrone-16-C14, the bile is the major excretory pathway of C14 excretion, unless this route is blocked. The urine then becomes the major excretory route. Very little of the radioactive biliary products was in the free form, practically all of the ether-extractable material was obtained after enzymatic hydrolysis. Administration of larger amounts of estrone-16-C14 increased the yield of the latter fraction which consisted mainly of non-estrogenic compounds, or of compounds with very weak estro-genic activity.Keywords
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