Congenital Deficiency of Fibrin-Stabilizing Factor

Abstract

SINCE the discovery by Laki and Lorand¹ of a plasma factor responsible for rendering a fibrin clot insoluble in 5-M urea and in 1 per cent monochloracetic acid in the presence of ionized calcium, the importance of Laki-Lorand factor,² also called fibrinase³ or fibrin-stabilizing factor (F.S.F.),⁴ has been recognized in the physiology of blood coagulation. The first researchers in this field concentrated on the identification,² purification,^{5 , 6} measure of activity⁷ and mechanism of action of this factor,⁸ but at that time, its clinical implications were still unknown.Since 1960, when Duckert et al.⁹ first observed a familial hemorrhagic disorder by congenital . . .