Action of Glucose and Insulin on Free Amino Acids of the Dehepatized Dog

Abstract

In the absence of the pancreas, admn. of glucose does not alter the accumulation of free amino acids that occurs after total removal of the liver. The admn. of insulin depresses this accumulation of amino acids. These observations suggest that the nitrogen-sparing action of glucose when the pancreas is present is caused by stimulation of the secretion of insulin. Insulin diminishes the amt. of free amino acids in muscle as well as in plasma apparently by increasing the rate of incorporation of free amino acids into protein. Insulin does not alter the concn. of total free amino acids or of glutamine in the brain.