CORRECTION OF DECREASED GUANYLATE-CYCLASE ACTIVITY IN DIABETIC RATS BY PANCREATIC-ISLET TRANSPLANTATION
- 1 January 1979
- journal article
- research article
- Vol. 27 (6), 403-405
Abstract
Streptozotocin-induced diabetic rats have decreased guanylate cyclase (EC 4.6.1.2) activity in liver and other tissues which was returned to normal by the administration of exogenous insulin. Since successful pancreatic islet transplants lower basal hepatic glucose output, gluconeognesis and urea production, pancreatic islet transplants seemed to be a more physiological model to test the in vivo effects of insulin on guanylate cyclase activity in diabetic animals. The present investigation demonstrated that pancreatic islet transplants into 2 different species of streptozotocin-induced diabetic rats increased the lowered activity of guanylate cyclase activity found in diabetic animals to the level of guanylate cyclase activity present in control animals.This publication has 8 references indexed in Scilit:
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