MYOTONIA ATROPHICA WITH TESTICULAR ATROPHY: URINARY EXCRETION OF INTERSTITIAL-CELL-STIMULATING (LUTEINIZING) HORMONE, ANDROGENS AND 17-KETOSTEROIDS*

Abstract

The regular association of testicular atrophy and occasionally of other endocrine abnormalities with myotonia atrophica (dystrophia myotonica) has suggested that the disorder may represent a concatenated pluriglandular disturbance of endocrine origin and be susceptible to treatment by endocrine replacement therapy. An alternative interpretation is that myotonia atrophica, rather than reflecting a primary endocrine disturbance, is simply a manifestation of genetically linked degenerative phenomena seen in various tissues derived from embryonic ectoderm and mesoderm.