Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice

Abstract

A series of 11 triazenes (X-C6H4N = NNRCH3) was characterized for toxicity in mice (LD50). The quantitative structure-activity relationship (QSAR) obtained for toxicity was compared with the QSAR for antitumor activity [mouse L1210 leukemia]. The close correspondence of the 2 QSAR leaves essentially no means for the synthesis of more potent, less toxic triazenes.