GLUCOSE ADMINISTRATION AUGMENTS IN VIVO UPTAKE AND PHOTOTOXICITY OF THE TUMOR‐LOCALIZING FRACTION OF HEMATOPORPHYRIN DERIVATIVE
- 1 March 1989
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 49 (3), 241-247
- https://doi.org/10.1111/j.1751-1097.1989.tb04102.x
Abstract
Rhabdomyosarcoma tumors in rats made hyperglycemic by multiple injections of glucose exhibited a transient decrease in pH and an increased ability to accumulate derivatives of hemato-porphyrin (HPD). Photoradiation of tumors in glucose/HPD-treated animals produced a greater cell kill than in galactose/HPD-treated controls. A therapeutic benefit of glucose administration in conjunction with HPD-phototherapy is suggested.This publication has 10 references indexed in Scilit:
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