Comparative detoxication. 6. The metabolism of 6-amino-4 nitro-o-cresol and 4:6-dinitro-o-cresol in locusts

Abstract

6-Amino-4-nitro-o-cresol is conjugated in the locusts Schistocerca gregaria and Locusta migratoria to 6-amino-4-nitro-o-cresyl glucoside and 6-amino-4-nitro-o-cresyl hydrogen sulfate, which have been identified in the gut and excreta by chromato-graphic, ionophoretic and spectroscopic methods. Small amounts of 6-acetamido-4-nitro-o-cresol were similarly identified in extracts of locusts poisoned with 4, 6-dinitro-o-cresol. [beta]-Glucosidase activity is present in the contents of locust fore-, mid- and hind-gut, and in locust excreta. Aryl sulfatase activity is present in locust fore-gut and mid-gut contents, and to a much smaller extent in hind-gut and excreta.