THROMBOTIC THROMBOCYTOPENIC PURPURA - A 10-YEAR EXPERIENCE

Abstract

Splenectomy, corticosteroids and antiplatelet agents have improved survival in thrombotic thrombocytopenic purpura (TTP). In 1974, successful treatment was reported of 5 of 6 patients using splenectomy, corticosteroids and average MW dextran. A 10 yr experience with TTP at Mount Sinai Hospital (MSH) [New York, USA] is described. Twenty patients with TTP were seen. Possible inciting factors included pregnancy, oral contraceptives and surgery. Splenectomy was performed in 18 patients and typical findings of TTP were found in 14 (78%). Fifteen patients were treated with splenectomy, corticosteroids and average MW dextran. Two of the 15 patients received, in addition, ASA [acetylsalicylic acid] and dipyridamole and a 3rd received only dipyridamole. Of the 15, 13 (87%) have survived and remain disease-free.