SYNTHESIS AND ANALGESIC ACTIVITY OF HUMAN β-ENDORPHIN ANALOGS SUBSTITUTED AT POSITIONS 17, 18, OR 19
- 12 January 2009
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 15 (2), 167-170
- https://doi.org/10.1111/j.1399-3011.1980.tb02564.x
Abstract
Three peptide analogs of .beta.-endorphin which are substituted in positions 17, 18 or 19 were synthesized and their analgesic potencies were measured by the tail-flick method in mice. The replacement of Phe-18 of Lys-19 by alanine reduced the potency to 15%, but the replacement of Leu-17 by alanine reduced the analgesic potency to 68%.Keywords
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