ADRENAL AUTOTRANSPLANTS WITH HEPATIC PORTAL DRAINAGE IN THE RAT

Abstract

Following bilateral adrenalectomy, either an entire adrenal or a portion of an adrenal was autotransplanted into the liver, the spleen or the kidney of the rat. The amt. of the gland transplanted and the percentage of animals surviving for more than 30 days has been as follows: entire in spleen - 85%; entire in liver - 71%; 1/2 in kidney - 69%; 1/2 in liver - 60%; 1/4 in kidney - 25%; and 1/4 in liver - 25%. In surviving transplants, regions of the capsule produced new areas of cells which often remained separated by septa. Normal zonation seldom occurred and there was no correlation between degree of zonation and support of life. The tissues of the liver and spleen appear to have no more inactivating effect on the cortical hormone than the tissues of the kidney.